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Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia.


ABSTRACT: Pancreatic cancer is one of the most aggressive cancers and has an extremely poor prognosis. Despite recent progress in both basic and clinical research, most pancreatic cancers are detected at an incurable stage owing to the absence of disease-specific symptoms. Thus, developing novel approaches for detecting pancreatic cancer at an early stage is imperative. Our in silico and immunohistochemical analyses showed that KIAA1199 is specifically expressed in human pancreatic cancer cells and pancreatic intraepithelial neoplasia, the early lesion of pancreatic cancer, in a genetically engineered mouse model and in human patient samples. We also detected secreted KIAA1199 protein in blood samples obtained from pancreatic cancer mouse models, but not in normal mice. Furthermore, we found that assessing KIAA1199 autoantibody increased the sensitivity of detecting pancreatic cancer. These results indicate the potential benefits of using KIAA1199 as a biomarker for early-stage pancreatic cancer.

SUBMITTER: Suh HN 

PROVIDER: S-EPMC5138641 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia.

Suh Han Na HN   Jun Sohee S   Oh Ah-Young AY   Srivastava Mrinal M   Lee Sunhye S   Taniguchi Cullen M CM   Zhang Songlin S   Lee Won Sup WS   Chen Junjie J   Park Bum-Joon BJ   Park Jae-Il JI  

Scientific reports 20161206


Pancreatic cancer is one of the most aggressive cancers and has an extremely poor prognosis. Despite recent progress in both basic and clinical research, most pancreatic cancers are detected at an incurable stage owing to the absence of disease-specific symptoms. Thus, developing novel approaches for detecting pancreatic cancer at an early stage is imperative. Our in silico and immunohistochemical analyses showed that KIAA1199 is specifically expressed in human pancreatic cancer cells and pancre  ...[more]

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