Ontology highlight
ABSTRACT:
SUBMITTER: Ahuja N
PROVIDER: S-EPMC11015051 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Ahuja Nancy N Gupta Shalini S Arora Rashmi R Bhagyaraj Ella E Tiwari Drishti D Kumar Sumit S Gupta Pawan P
Life science alliance 20240412 7
Elevated ER stress has been linked to the pathogenesis of several disease conditions including neurodegeneration. In this study, we have holistically determined the differential expression of all the nuclear receptors (NRs) in the presence of classical ER stress inducers. Activation of Nr1h4 and Thrb by their cognate ligands (GW4064 and T3) ameliorates the tunicamycin (TM)-induced expression of ER stress genes. A combination of both ligands is effective in mitigating cell death induced by TM. Fu ...[more]