Ontology highlight
ABSTRACT:
SUBMITTER: Fan Z
PROVIDER: S-EPMC11019538 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
Fan Zixing Z Pavlova Anna A Jenkins Matthew C MC Bassit Leda L Salman Mohammad M Lynch Diane L DL Patel Dharmeshkumar D Korablyov Maksym M Finn M G MG Schinazi Raymond F RF Gumbart James C JC
ACS infectious diseases 20240402 4
Hepatitis B virus (HBV) is the leading cause of chronic liver pathologies worldwide. HBV nucleocapsid, a key structural component, is formed through the self-assembly of the capsid protein units. Therefore, interfering with the self-assembly process is a promising approach for the development of novel antiviral agents. Applied to HBV, this approach has led to several classes of capsid assembly modulators (CAMs). Here, we report structurally novel CAMs with moderate activity and low toxicity, dis ...[more]