The interleukin-17 gene of herpesvirus saimiri.
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ABSTRACT:
SUBMITTER: Knappe A
PROVIDER: S-EPMC110381 | biostudies-literature | 1998 Jul
REPOSITORIES: biostudies-literature
Publications
The interleukin-17 gene of herpesvirus saimiri.
Knappe A A Hiller C C Niphuis H H Fossiez F F Thurau M M Wittmann S S Kuhn E M EM Lebecque S S Banchereau J J Rosenwirth B B Fleckenstein B B Heeney J J Fickenscher H H
Journal of virology 19980701 7
In comparison to wild-type herpesvirus saimiri, viral interleukin-17 gene knockout mutants have unaltered behavior regarding viral replication, T-cell transformation in vitro, and pathogenicity in cottontop tamarins. Thus, this gene is not required for T-cell lymphoma induction but may contribute to apathogenic viral persistence in the natural host, the squirrel monkey. ...[more]
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