Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri.
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ABSTRACT:
SUBMITTER: Knappe A
PROVIDER: S-EPMC111897 | biostudies-literature | 2000 Apr
REPOSITORIES: biostudies-literature
Publications
Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri.
Knappe A A Hör S S Wittmann S S Fickenscher H H
Journal of virology 20000401 8
Although herpesvirus saimiri-transformed T lymphocytes retain multiple normal T-cell functions, only a few changes have been described. By subtractive hybridization, we have isolated a novel cellular gene, ak155, a sequence homolog of the interleukin-10 gene. Specifically herpesvirus saimiri-transformed T cells overexpress ak155 and secrete the protein into the supernatant. In other T-cell lines and in native peripheral blood cells, but not in B cells, ak155 is transcribed at low levels. AK155 f ...[more]
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