Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto H
PROVIDER: S-EPMC110665 | biostudies-literature | 1998 May
REPOSITORIES: biostudies-literature
Yamamoto H H Kishida S S Uochi T T Ikeda S S Koyama S S Asashima M M Kikuchi A A
Molecular and cellular biology 19980501 5
Using a yeast two-hybrid method, we identified a novel protein which interacts with glycogen synthase kinase 3beta (GSK-3beta). This protein had 44% amino acid identity with Axin, a negative regulator of the Wnt signaling pathway. We designated this protein Axil for Axin like. Like Axin, Axil ventralized Xenopus embryos and inhibited Xwnt8-induced Xenopus axis duplication. Axil was phosphorylated by GSK-3beta. Axil bound not only to GSK-3beta but also to beta-catenin, and the GSK-3beta-binding s ...[more]