Ontology highlight
ABSTRACT:
SUBMITTER: Dajani R
PROVIDER: S-EPMC140752 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
Dajani Rana R Fraser Elizabeth E Roe S Mark SM Yeo Maggie M Good Valerie M VM Thompson Vivienne V Dale Trevor C TC Pearl Laurence H LH
The EMBO journal 20030201 3
Glycogen synthase kinase 3beta (GSK3beta) is a serine/threonine kinase involved in insulin, growth factor and Wnt signalling. In Wnt signalling, GSK3beta is recruited to a multiprotein complex via interaction with axin, where it hyperphosphorylates beta-catenin, marking it for ubiquitylation and destruction. We have now determined the crystal structure of GSK3beta in complex with a minimal GSK3beta-binding segment of axin, at 2.4 A resolution. The structure confirms the co-localization of the bi ...[more]