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A single amino acid change in the murine leukemia virus capsid gene responsible for the Fv1(nr) phenotype.

ABSTRACT: The nr allele at the mouse Fv1 restriction locus governs resistance to B-tropic and some N-tropic murine leukemia viruses (MLVs). Sequence analysis and site-specific mutagenesis of N-tropic MLVs identified a single amino acid difference responsible for this restriction that is distinct from the site that governs N or B tropism. Viruses with other substitutions at this site were evaluated for altered replication patterns.

SUBMITTER: Jung YT

PROVIDER: S-EPMC110898 | biostudies-literature | 2000 Jun

REPOSITORIES: biostudies-literature

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A single amino acid change in the murine leukemia virus capsid gene responsible for the Fv1(nr) phenotype.

Jung Y T YT Kozak C A CA

Journal of virology 20000601 11

The nr allele at the mouse Fv1 restriction locus governs resistance to B-tropic and some N-tropic murine leukemia viruses (MLVs). Sequence analysis and site-specific mutagenesis of N-tropic MLVs identified a single amino acid difference responsible for this restriction that is distinct from the site that governs N or B tropism. Viruses with other substitutions at this site were evaluated for altered replication patterns. ...[more]

PMID: 10799620

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