Ontology highlight
ABSTRACT:
SUBMITTER: Bui YK
PROVIDER: S-EPMC111133 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Bui Yen Kim YK Sternberg Paul W PW
Molecular biology of the cell 20020501 5
Ovulation in Caenorhabditis elegans requires inositol 1,4,5-triphosphate (IP(3)) signaling activated by the epidermal growth factor (EGF)-receptor homolog LET-23. We generated a deletion mutant of a type I 5-phosphatase, ipp-5, and found a novel ovulation phenotype whereby the spermatheca hyperextends to engulf two oocytes per ovulation cycle. The temporal and spatial expression of IPP-5 is consistent with its proposed inhibition of IP(3) signaling in the adult spermatheca. ipp-5 acts downstream ...[more]