Ontology highlight
ABSTRACT:
SUBMITTER: Gower NJ
PROVIDER: S-EPMC1196312 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Gower Nicholas J D NJ Walker Denise S DS Baylis Howard A HA
Molecular biology of the cell 20050615 9
Complex behavior requires the coordinated action of the nervous system and nonneuronal targets. Male mating in Caenorhabditis elegans consists of a series of defined behavioral steps that lead to the physiological outcomes required for successful impregnation. We demonstrate that signaling mediated by inositol 1,4,5-trisphosphate (IP(3)) is required at several points during mating. Disruption of IP(3) receptor (itr-1) function results in dramatic loss of male fertility, due to defects in turning ...[more]