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ABSTRACT: Objectives
Encephalitis is a severe neurological syndrome for which herpesvirus and enteroviruses are the most common etiological agents. Arboviruses, a wildly diverse group of pathogens, are also critical epidemiological agents associated with encephalitis. In Brazil, little is known about the causative agents of encephalitis.Methods
We conducted a hospital surveillance for encephalitis between 2020 and 2022. Molecular (RT-PCR and qPCR) and serological (virus-specific IgM and viral antigens) techniques were performed in cerebrospinal fluid and serum samples obtained from study participants.Results
In the 43 participants evaluated, the etiologic agent or the presence of IgM was detected in 16 (37.2%). Nine (20.9%) cases were positive for chikungunya virus (CHIKV), three (7.0%) for dengue virus, two (4.7%) for human adenovirus, one (2.3%) for varicella-zoster virus, and one (2.3%) for enterovirus. Whole-genome sequencing revealed that the CHIKV identified belongs to the East/Central/South African lineage.Conclusion
Herein, CHIKV is a common pathogen identified in encephalitis cases. Our results reinforce previous evidence that chikungunya represents a significant cause of encephalitis during CHIKV outbreaks and epidemics and add to existing information on the epidemiology of encephalitis in Brazil.
SUBMITTER: Sampaio MPS
PROVIDER: S-EPMC11183300 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Sampaio Maria Paula de Souza MPS do Rosário Mateus Santana MS Martins Lorena Cunha LC Trindade Luiza Vieira Luedy LVL Francisco Marcos Vinicius Lima de Oliveira MVLO Costa Bernardo Gratival Gouvea BGG Vasconcelos Gessica Almeida GA Lima Italo Andrade Barbosa IAB Macêdo Yasmin Santos Freitas YSF Carvalho Fernanda Maria Lessa FML de Santana Marina Borges Rabelo MBR Khouri Ricardo R Fritsch Hegger H Xavier Joilson J Fonseca Vagner V Giovanetti Marta M de Mello Arabela Leal E Silva ALES Pereira Felicidade Mota FM Campos Gubio Soares GS de Jesus Pedro Antonio Pereira PAP Farias Daniel Santana DS de Souza Murilo Santos MS Galvão Adilson Junior Pinto AJP Costa Felipe Oliveira FO Bessa Marcia Carvalho MC Chagas Janeusa Rita Leite Primo JRLP Silvany Celia C Teles Jose Mário Meira JMM de Lima Maricelia Maia MM Farias Tarsis Leonardo Almeida TLA Gräf Tiago T de Siqueira Isadora Cristina IC
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20240516
<h4>Objectives</h4>Encephalitis is a severe neurological syndrome for which herpesvirus and enteroviruses are the most common etiological agents. Arboviruses, a wildly diverse group of pathogens, are also critical epidemiological agents associated with encephalitis. In Brazil, little is known about the causative agents of encephalitis.<h4>Methods</h4>We conducted a hospital surveillance for encephalitis between 2020 and 2022. Molecular (RT-PCR and qPCR) and serological (virus-specific IgM and vi ...[more]