Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC11222436 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Zhang Yi Y Zhou Shuyan S Kai Yan Y Zhang Ya-Qin YQ Peng Changmin C Li Zhuqing Z Mughal Muhammad Jameel MJ Julie Belmar B Zheng Xiaoyan X Ma Junfeng J Ma Cynthia X CX Shen Min M Hall Matthew D MD Li Shunqiang S Zhu Wenge W
Nature communications 20240703 1
Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle and cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to CDK4/6 inhibitors (CDK4/6i), such as palbociclib, remains a substantial challenge in clinical settings. Using high-throughput combinatorial drug screening and genomic sequencing, we find that the microphthalmia-associated transcription factor (MITF) is activated via O-GlcNAcylation by O-GlcNAc transfe ...[more]