Ontology highlight
ABSTRACT:
SUBMITTER: Furuya H
PROVIDER: S-EPMC11226602 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Furuya Hiroki H Toda Yosuke Y Iwata Arifumi A Kanai Mizuki M Kato Kodai K Kumagai Takashi T Kageyama Takahiro T Tanaka Shigeru S Fujimura Lisa L Sakamoto Akemi A Hatano Masahiko M Suto Akira A Suzuki Kotaro K Nakajima Hiroshi H
Nature communications 20240705 1
Group 2 innate lymphoid cells (ILC2s) are a subset of innate lymphocytes that produce type 2 cytokines, including IL-4, IL-5, and IL-13. GATA3 is a critical transcription factor for ILC2 development at multiple stages. However, when and how GATA3 is induced to the levels required for ILC2 development remains unclear. Herein, we identify ILC2-specific GATA3-related tandem super-enhancers (G3SE) that induce high GATA3 in ILC2-committed precursors. G3SE-deficient mice exhibit ILC2 deficiency in the ...[more]