Ontology highlight
ABSTRACT:
SUBMITTER: Xu W
PROVIDER: S-EPMC3587319 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Xu Wei W Carr Tiffany T Ramirez Kevin K McGregor Stephanie S Sigvardsson Mikael M Kee Barbara L BL
Blood 20130107 9
The E2A transcription factors promote the development of thymus-seeding cells, but it remains unknown whether these proteins play a role in T lymphocyte lineage specification or commitment. Here, we showed that E2A proteins were required to promote T-lymphocyte commitment from DN2 thymocytes and to extinguish their potential for alternative fates. E2A proteins functioned in DN2 cells to limit expression of Gata3, which encodes an essential T-lymphocyte transcription factor whose ectopic expressi ...[more]