Dataset Information

Prevalence and risk factors predisposing low bone mineral density in patients with thalassemia.

ABSTRACT:

Background

A common complication of thalassemia is secondary osteoporosis. This study aimed to assess the prevalence and factors associated with low BMD in thalassemic patients.

Method

This is a cross-sectional study. Eligible patients were males aged within 18-49 years or premenopausal women diagnosed with thalassemia in Chiang Mai University Hospital between July 2021 and July 2022. The diagnosis of low BMD by dual-energy x-ray absorptiometry (DXA) was defined as a Z-score of -2.0 SD or lower in either the lumbar spine or femoral neck. Clinical factors associated with low BMD were analyzed using a logistic regression model.

Results

Prevalence of low BMD was 62.4% from 210 patients with a mean age of 29.7 ± 7.6 years. The predominant clinical characteristics of low BMD thalassemia patients were being female, transfusion-dependent (TDT) and a history of splenectomy. From multivariable analysis, the independent variables associated with low BMD were transfusion dependency (odds ratio, OR 2.36; 95%CI 1.28 to 4.38; p=0.006) and body mass index (BMI) (OR 0.71; 95%CI 0.61 to 0.82; p<0.001). Among patients with low BMD, we observed a correlation between a Z-score with low IGF-1 levels (β=-0.42; 95% CI -0.83 to -0.01; p=0.040), serum phosphate levels (β=0.40; 95% CI 0.07 to 0.73; p=0.016) and hypogonadism (β=-0.48, 95% CI -0.91 to -0.04, p=0.031).

Conclusion

This study found a prevalence of low BMD in 62.4% of subjects. Factors associated with low BMD were TDT and BMI. Within the low BMD subgroup, hypogonadism, serum phosphate and low serum IGF-1 levels were associated with a lower Z-score.

SUBMITTER: Ananvutisombat N

PROVIDER: S-EPMC11228236 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Prevalence and risk factors predisposing low bone mineral density in patients with thalassemia.

Ananvutisombat Natnicha N Tantiworawit Adisak A Punnachet Teerachat T Hantrakun Nonthakorn N Piriyakhuntorn Pokpong P Rattanathammethee Thanawat T Hantrakool Sasinee S Chai-Adisaksopha Chatree C Rattarittamrong Ekarat E Norasetthada Lalita L Fanhchaksai Kanda K Charoenkwan Pimlak P

Frontiers in endocrinology 20240624

<h4>Background</h4>A common complication of thalassemia is secondary osteoporosis. This study aimed to assess the prevalence and factors associated with low BMD in thalassemic patients.<h4>Method</h4>This is a cross-sectional study. Eligible patients were males aged within 18-49 years or premenopausal women diagnosed with thalassemia in Chiang Mai University Hospital between July 2021 and July 2022. The diagnosis of low BMD by dual-energy x-ray absorptiometry (DXA) was defined as a Z-score of -2 ...[more]

PMID: 38978629

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Project description:BackgroundSufficient bone quality is a prerequisite for low complication rates and satisfactory outcomes in lumbar fusion surgery (LFS). Low bone mineral density (BMD), including osteoporosis and osteopenia, is linked to adverse postoperative outcomes. Despite reports of a high prevalence of undiagnosed osteoporosis, it is uncertain which risk factors should guide preoperative BMD screening in LFS.MethodsThis secondary cross-sectional analysis of a prospective institutional database at an academic spine center included adult patients undergoing LFS for degenerative conditions between 2014 and 2023. Opportunistic quantitative CT (qCT) at the L1/2 level was performed before surgery, and demographic and medical history data were extracted. Descriptive and comparative statistics, univariable and multivariable logistic regression were performed to determine risk factors for present and undiagnosed osteoporosis.ResultsOf the 675 patients screened, 578 (54% female) were included after excluding those with preoperative lumbar CT scans not suitable for qCT. The median age was 65 years (IQR 58-72), and the median BMI of 28.9 kg/m2 (IQR 25.2-32.9). Osteoporosis was identified in 182 patients (31%), with 114 previously diagnosed and 68 newly detected via preoperative qCT. Undiagnosed osteoporosis was found in 12% of all patients and 37% of those with osteoporosis. Osteopenia was present in 199 patients (34%), leading to an overall impaired bone quality prevalence of 66%. Multivariable analysis revealed that age and female sex were independent risk factors for osteoporosis, while undiagnosed cases were more common in males, patients with higher BMI, and older individuals.ConclusionsThis study found a high prevalence of abnormal BMD in LFS patients, with a significant proportion of undiagnosed osteoporosis. While osteoporosis was more common in females, male patients with osteoporosis were more frequently undiagnosed. Spine surgeons must remain vigilant about metabolic bone disease in LFS patients to ensure preoperative optimization and prevent complications.

Project description:Introduction: Chronic pancreatitis (CP) can lead to malnutrition, an established risk factor for low bone mineral density (BMD) and fractures. This study aims to determine the prevalence of low BMD, assess fracture incidence and explore risk factors for fractures in patients with CP. Patients and methods: We performed a retrospective analysis of all patients treated for CP at Karolinska University Hospital between January 1999 and December 2020. Electronic medical records were retrieved to assess demographic, laboratory and clinical data. Patients subjected to dual-energy X-ray absorptiometry (DXA) were categorised as either low BMD or normal BMD. We investigated whether the rate of fractures, defined by chart review, differed between these groups using Cox regression, adjusting the model for age, sex and body mass index (BMI). Additional within-group survival analysis was conducted to identify potential risk factors. Results: DXA was performed in 23% of patients with definite CP. Some 118 patients were included in the final analysis. Low BMD was present in 63 (53.4%) patients. Mean age at CP diagnosis in the total cohort was 53.1 years and was significantly lower in patients with normal BMD than in patients with low BMD (45.5 vs. 59.8, p < 0.001). Significant differences were observed in smoking status and disease aetiology, i.e., a higher proportion of patients with low BMD were current or former smokers, with nicotine or alcohol being a more common cause of CP (p < 0.05). Total follow-up time was 898 person-years. Fractures were found in 33 (28.0%) patients: in 5 of 55 patients (16.7%) with normal DXA and in 28 of 63 patients (44.4%) with low BMD (adjusted hazard ratio = 3.4, 95% confidence interval (CI) = 1.2-9.6). Patients with at least 3 months of consecutive pancreatic enzyme replacement therapy (PERT) or vitamin D treatment had a longer median time to fracture after CP diagnosis. Conclusion: DXA was only performed in 23% of patients with definite CP in this study, indicating a low adherence to current European guidelines. A low BMD was found in 53.4% of patients with CP, and 44% of the patients with a low BMD experienced a fracture during follow-up. Moreover, the fracture rate in patients with low BMD increased compared to those with normal BMD.

Dataset Information

Prevalence and risk factors predisposing low bone mineral density in patients with thalassemia.

Background

Method

Results

Conclusion

Publications

Prevalence and risk factors predisposing low bone mineral density in patients with thalassemia.

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