Postmortem tissue biomarkers of menopausal transition.
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ABSTRACT:
SUBMITTER: Tickerhoof M
PROVIDER: S-EPMC11230159 | biostudies-literature | 2024 Jun
REPOSITORIES: biostudies-literature
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Postmortem tissue biomarkers of menopausal transition.
Tickerhoof Maria M Cham Heining H Ger Anaya A Burrja Sonola S Auluck Pavan P Schmidt Peter J PJ Marenco Stefano S Kundakovic Marija M
bioRxiv : the preprint server for biology 20240624
The menopausal transition (MT) is associated with an increased risk for many disorders including neurological and mental disorders. Brain imaging studies in living humans show changes in brain metabolism and structure that may contribute to the MT-associated brain disease risk. Although deficits in ovarian hormones have been implicated, cellular and molecular studies of the brain undergoing MT are currently lacking, mostly due to a difficulty in studying MT in postmortem human brain. To enable t ...[more]
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