Ontology highlight
ABSTRACT:
SUBMITTER: Seitz MP
PROVIDER: S-EPMC11234337 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Seitz Michael P MP Song Yuanhui Y Lian Xiaojun Lance XL Ma Zhen Z Jain Era E
ACS biomaterials science & engineering 20240618 7
Lumenogenesis within the epiblast represents a critical step in early human development, priming the embryo for future specification and patterning events. However, little is known about the specific mechanisms that drive this process due to the inability to study the early embryo in vivo. While human pluripotent stem cell (hPSC)-based models recapitulate many aspects of the human epiblast, most approaches for generating these 3D structures rely on ill-defined, reconstituted basement membrane ma ...[more]