Ontology highlight
ABSTRACT:
SUBMITTER: Vassileff N
PROVIDER: S-EPMC11249427 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Vassileff Natasha N Spiers Jereme G JG Lee John D JD Woodruff Trent M TM Ebrahimie Esmaeil E Mohammadi Dehcheshmeh Manijeh M Hill Andrew F AF Cheng Lesley L
Molecular neurobiology 20240122 8
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease characterised by the deposition of aggregated proteins including TAR DNA-binding protein 43 (TDP-43) in vulnerable motor neurons and the brain. Extracellular vesicles (EVs) facilitate the spread of neurodegenerative diseases and can be easily accessed in the bloodstream. This study aimed to identify a panel of EV miRNAs that can capture the pathology occurring in the brain and peripheral circulation. EVs were isolated from ...[more]