Dataset Information

High baseline perivascular space volume in basal ganglia is associated with attention and executive function decline in Parkinson's disease.

ABSTRACT:

Background

Pathologic perivascular spaces (PVS), the fluid-filled compartments surrounding brain vasculature, may underlie cognitive decline in Parkinson's disease (PD). However, whether this impacts specific cognitive domains has not been investigated.

Objectives

This study examined the relationship of PVS volume at baseline with domain-specific and global cognitive change over 2 years in PD individuals.

Methods

A total of 39 individuals with PD underwent 3T T1w magnetic resonance imaging to determine PVS volume fraction (PVS volume normalized to total regional volume) within (i) centrum semiovale, (ii) prefrontal white matter (medial orbitofrontal, rostral middle frontal, and superior frontal), and (iii) basal ganglia. A neuropsychological battery included assessment of cognitive domains and global cognitive function at baseline and after 2 years.

Results

Higher basal ganglia PVS at baseline was associated with greater decline in attention, executive function, and global cognition scores.

Conclusions

While previous reports have associated elevated PVS volume in the basal ganglia with decline in global cognition in PD, our findings show such decline may affect the attention and executive function domains.

SUBMITTER: Foreman RP

PROVIDER: S-EPMC11250171 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature

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Publications

High baseline perivascular space volume in basal ganglia is associated with attention and executive function decline in Parkinson's disease.

Foreman Ryan Patrick RP Donahue Erin Kaye EK Duran Jared Joshua JJ Schiehser Dawn M DM Petkus Andrew A O'Neill Joseph J Holschneider Daniel Phillip DP Choupan Jeiran J Van Horn John Darrell JD Bayram Ece E Litvan Irene I Jakowec Michael Walter MW Petzinger Giselle Maria GM

Brain and behavior 20240701 7

<h4>Background</h4>Pathologic perivascular spaces (PVS), the fluid-filled compartments surrounding brain vasculature, may underlie cognitive decline in Parkinson's disease (PD). However, whether this impacts specific cognitive domains has not been investigated.<h4>Objectives</h4>This study examined the relationship of PVS volume at baseline with domain-specific and global cognitive change over 2 years in PD individuals.<h4>Methods</h4>A total of 39 individuals with PD underwent 3T T1w magnetic r ...[more]

PMID: 39010690

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Project description:Background and objectiveRecent studies suggest perivascular spaces are a marker of small vessel disease, blood-brain barrier permeability, and inflammation, but little is known about their risk factors and associations with peripheral blood markers.Materials and methodsIn prospectively recruited patients with recent minor ischemic stroke, we investigated the influence of age, sex, hypertension, diabetes, and smoking on the severity of perivascular spaces in the basal ganglia seen on T2-weighted magnetic resonance imaging. We assessed plasma markers of endothelial function (von Willebrand factor, intracellular adhesion molecule-1), inflammation (interleukin-6, tumor necrosis factor-alpha, C-reactive protein), and thrombosis (fibrinogen, prothrombin fragments 1 + 2, thrombin-antithrombin complex, tissue plasminogen activator, D-dimer). We used a validated semi-automated method to measure basal ganglia perivascular spaces count and volume. We tested uni- and multivariable associations between blood markers and basal ganglia perivascular spaces count and volume.FindingsIn 100 patients (median age: 67 years, range: 37-92), on adjusted analysis, basal ganglia perivascular spaces count was associated with age (r = .117, P = .003) and hypertension (r = 2.225, P = .013). On multivariable linear regression, adjusted for age, sex, hypertension, smoking and diabetes, reduced von Willebrand factor was associated with increased basal ganglia perivascular spaces count (r = -.025, P = .032).ConclusionThe association of increased basal ganglia perivascular spaces count with reduced von Willebrand factor is novel. As von Willebrand factor may promote cerebral endothelial integrity, insufficient von Willebrand factor is consistent with dysfunctional cerebral endothelium and increased basal ganglia perivascular spaces in cerebral small vessel disease. Quantitative perivascular spaces measurement may increase sensitivity to detect cerebral endothelial dysfunction.

Dataset Information

High baseline perivascular space volume in basal ganglia is associated with attention and executive function decline in Parkinson's disease.

Background

Objectives

Methods

Results

Conclusions

Publications

High baseline perivascular space volume in basal ganglia is associated with attention and executive function decline in Parkinson's disease.

Similar Datasets

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