Ontology highlight
ABSTRACT:
SUBMITTER: Pan D
PROVIDER: S-EPMC11259713 | biostudies-literature | 2024 May
REPOSITORIES: biostudies-literature
Pan Deyuan D Long Lin L Li Chengyu C Zhou Yingxin Y Liu Qing Q Zhao Ziting Z Zhao Hui H Lin Wan W Zheng Zhenyuan Z Peng Liu L Li Enmin E Xu Liyan L
The Journal of biological chemistry 20240527 7
Lysyl oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family and has the ability to catalyze the cross-linking of extracellular matrix collagen and elastin. High expression of LOXL2 is related to tumor cell proliferation, invasion, and metastasis. LOXL2 contains 14 exons. Previous studies have found that LOXL2 has abnormal alternative splicing and exon skipping in a variety of tissues and cells, resulting in a new alternatively spliced isoform denoted LOXL2Δ13. LOXL2Δ13 lacks LOXL2WT exo ...[more]