Ontology highlight
ABSTRACT:
SUBMITTER: Giampietro C
PROVIDER: S-EPMC4633719 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Giampietro Costanza C Deflorian Gianluca G Gallo Stefania S Di Matteo Anna A Pradella Davide D Bonomi Serena S Belloni Elisa E Nyqvist Daniel D Quaranta Valeria V Confalonieri Stefano S Bertalot Giovanni G Orsenigo Fabrizio F Pisati Federica F Ferrero Elisabetta E Biamonti Giuseppe G Fredrickx Evelien E Taveggia Carla C Wyatt Chris D R CD Irimia Manuel M Di Fiore Pier Paolo PP Blencowe Benjamin J BJ Dejana Elisabetta E Ghigna Claudia C
Nature communications 20151008
Vascular lumen formation is a fundamental step during angiogenesis; yet, the molecular mechanisms underlying this process are poorly understood. Recent studies have shown that neural and vascular systems share common anatomical, functional and molecular similarities. Here we show that the organization of endothelial lumen is controlled at the post-transcriptional level by the alternative splicing (AS) regulator Nova2, which was previously considered to be neural cell-specific. Nova2 is expressed ...[more]