Ontology highlight
ABSTRACT:
SUBMITTER: Zhou X
PROVIDER: S-EPMC11286957 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Zhou Xin X Levesque Paul P Chaudhary Khuram K Davis Myrtle M Rodriguez Blanca B
Scientific reports 20240729 1
Chronic heart failure is one of the most common reasons for hospitalization. Current risk stratification is based on ejection fraction, whereas many arrhythmic events occur in patients with relatively preserved ejection fraction. We aim to investigate the mechanistic link between proarrhythmic abnormalities, reduced contractility and diastolic dysfunction in heart failure, using electromechanical modelling and simulations of human failing cardiomyocytes. We constructed, calibrated and validated ...[more]