Ontology highlight
ABSTRACT:
SUBMITTER: Han P
PROVIDER: S-EPMC3197373 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Han Peidong P Cai Wenfeng W Wang Yanru Y Lam Chi Keung CK Arvanitis Demetrios A DA Singh Vivek P VP Chen Shan S Zhang Huiliang H Zhang Rongli R Cheng Heping H Kranias Evangelia G EG
American journal of physiology. Heart and circulatory physiology 20110708 4
The histidine-rich calcium binding protein (HRC) Ser96Ala polymorphism was shown to correlate with ventricular arrhythmias and sudden death only in dilated cardiomyopathy patients but not in healthy human carriers. In the present study, we assessed the molecular and cellular mechanisms underlying human arrhythmias by adenoviral expression of the human wild-type (HRC(WT)) or mutant HRC (HRC(S96A)) in adult rat ventricular cardiomyocytes. Total HRC protein was increased by ∼50% in both HRC(WT)- an ...[more]