Ontology highlight
ABSTRACT:
SUBMITTER: Cubitt CC
PROVIDER: S-EPMC11291271 | biostudies-literature | 2024 May
REPOSITORIES: biostudies-literature
Cubitt Celia C CC Wong Pamela P Dorando Hannah K HK Foltz Jennifer A JA Tran Jennifer J Marsala Lynne L Marin Nancy D ND Foster Mark M Schappe Timothy T Fatima Hijab H Becker-Hapak Michelle M Zhou Alice Y AY Hwang Kimberly K Jacobs Miriam T MT Russler-Germain David A DA Mace Emily M EM Berrien-Elliott Melissa M MM Payton Jacqueline E JE Fehniger Todd A TA
The Journal of clinical investigation 20240528 15
The surface receptor CD8α is present on 20%-80% of human (but not mouse) NK cells, yet its function on NK cells remains poorly understood. CD8α expression on donor NK cells was associated with a lack of therapeutic responses in patients with leukemia in prior studies, thus, we hypothesized that CD8α may affect critical NK cell functions. Here, we discovered that CD8α- NK cells had improved control of leukemia in xenograft models compared with CD8α+ NK cells, likely due to an enhanced capacity fo ...[more]