Ontology highlight
ABSTRACT:
SUBMITTER: Yin Y
PROVIDER: S-EPMC11296349 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Yin Ying Y Park Cheon-Gyu CG Zhang Feng F G Fedor Justin J Feng Shasha S Suo Yang Y Im Wonpil W Lee Seok-Yong SY
Science advances 20240802 31
Our sensory adaptation to cold and chemically induced coolness is mediated by the intrinsic property of TRPM8 channels to desensitize. TRPM8 is also implicated in cold-evoked pain disorders and migraine, highlighting its inhibitors as an avenue for pain relief. Despite the importance, the mechanisms of TRPM8 desensitization and inhibition remained unclear. We found, using cryo-electron microscopy, electrophysiology, and molecular dynamics simulations, that TRPM8 inhibitors bind selectively to th ...[more]