Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC3428855 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Zhang Xuming X Mak Stephanie S Li Lin L Parra Andres A Denlinger Bristol B Belmonte Carlos C McNaughton Peter A PA
Nature cell biology 20120701 8
Activation of the TRPM8 ion channel in sensory nerve endings produces a sensation of pleasant coolness. Here we show that inflammatory mediators such as bradykinin and histamine inhibit TRPM8 in intact sensory nerves, but do not do so through conventional signalling pathways. The G-protein subunit Gα(q) instead binds to TRPM8 and when activated by a Gq-coupled receptor directly inhibits ion channel activity. Deletion of Gα(q) largely abolished inhibition of TRPM8, and inhibition was rescued by a ...[more]