Ontology highlight
ABSTRACT:
SUBMITTER: Kawaguchi T
PROVIDER: S-EPMC11299556 | biostudies-literature | 2024 Sep
REPOSITORIES: biostudies-literature
Biochemistry and biophysics reports 20240713
Myriocin is an inhibitor of serine palmitoyltransferase involved in the initial biosynthetic step for sphingolipids, and causes potent growth inhibition in eukaryotic cells. In budding yeast, Rsb1, Rta1, Pug1, and Ylr046c are known as the Lipid-Translocating Exporter (LTE) family and believed to contribute to export of various cytotoxic lipophilic compounds. It was reported that Rsb1 is a transporter responsible for export of intracellularly accumulated long-chain bases, which alleviate the cyto ...[more]