Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC11304234 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Zhang Lu L Fang Zhengying Z Zhu Qingqing Q Yang Shumin S Fu Jia J Sun Zeguo Z Lu Geming G Wei Chengguo C Zhang Zhi Z Lee Kyung K Zhong Yifei Y Liu Ruijie R He John Cijiang JC
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20240530 29
Cholesterol 25-hydroxylase (CH25H), an enzyme involved in cholesterol metabolism, regulates inflammatory responses and lipid metabolism. However, its role in kidney disease is not known. The author found that CH25H transcript is expressed mostly in glomerular and peritubular endothelial cells and that its expression increased in human and mouse diabetic kidneys. Global deletion of Ch25h in Lepr<sup>db/db</sup> mice aggravated diabetic kidney disease (DKD), which is associated with increased en ...[more]