Baculovirus stimulates antiviral effects in mammalian cells.
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ABSTRACT:
SUBMITTER: Gronowski AM
PROVIDER: S-EPMC113044 | biostudies-literature | 1999 Dec
REPOSITORIES: biostudies-literature
Publications
Baculovirus stimulates antiviral effects in mammalian cells.
Gronowski A M AM Hilbert D M DM Sheehan K C KC Garotta G G Schreiber R D RD
Journal of virology 19991201 12
Herein, we report that Autographa californica nucleopolyhedrovirus, a member of the Baculoviridae family, is capable of stimulating antiviral activity in mammalian cells. Baculoviruses are not pathogenic to mammalian cells. Nevertheless, live baculovirus is shown here to induce interferons (IFN) from murine and human cell lines and induces in vivo protection of mice from encephalomyocarditis virus infection. Monoclonal antibodies specific for the baculovirus envelope gp67 neutralize baculovirus- ...[more]
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