Dataset Information

Beyond the acute: pain in long COVID survivors at 1.5 years.

ABSTRACT:

Objective

Long COVID, characterized by persistent symptoms post-acute COVID-19, remains a subject of intense investigation. This study focuses on pain, a common and notable symptom reported by long COVID patients.

Method

A cohort of 191 individuals, initially diagnosed with mild-to-moderate COVID-19, was followed up 1.5 years later to assess the frequency, clinical characteristics, and factors associated with pain persistence.

Results

Our study revealed that 31.9% of participants experienced at least one persistent pain symptom after 1.5 years. Headache emerged as the most prevalent symptom (29.8%), followed by myalgia (5.8%) and neuropathic pain (4.2%). Factors such as female gender and the presence of neuropathic pain symptom were identified as predictors of long-term headaches. Myalgia, showed associations with headache, arthralgia, and low ferritin levels. Persistent neuropathic pain symptom (4.2%) was linked to older age, female gender, sore throat, and headache.

Conclusion

This study provides insights into the evolution of pain symptoms over time after COVID-19 infection, emphasizing the interconnection between different pain syndromes. This research contributes to understanding the diverse and evolving nature of pain in long COVID survivors, offering valuable insights for targeted interventions and further investigations into the underlying mechanisms of persistent pain.

SUBMITTER: Oguz-Akarsu E

PROVIDER: S-EPMC11306299 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature

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Publications

Beyond the acute: pain in long COVID survivors at 1.5 years.

Oguz-Akarsu Emel E Gullu Gizem G Kilic Erhan E Dinç Yasemin Y Akdag Gonul G Rehber Cansu C Karli Necdet N

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20240531 9

<h4>Objective</h4>Long COVID, characterized by persistent symptoms post-acute COVID-19, remains a subject of intense investigation. This study focuses on pain, a common and notable symptom reported by long COVID patients.<h4>Method</h4>A cohort of 191 individuals, initially diagnosed with mild-to-moderate COVID-19, was followed up 1.5 years later to assess the frequency, clinical characteristics, and factors associated with pain persistence.<h4>Results</h4>Our study revealed that 31.9% of partic ...[more]

PMID: 38819528

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Project description:BackgroundIn developing settings, comparative data on COVID hospitalised survivors (HS) and non-hospitalised survivors (NHS) is scarce. We determined burdens, incidence, evolution, and associated factors of long COVID-19 over two years among these groups.MethodsWe conducted a longitudinal cohort study in Dhaka, Bangladesh, and recruited confirmed COVID-19 survivors from December 2020 to May 2021 (previously reported). 346 survivors underwent in-person follow-ups at five, nine, 18 months and two years post-infection. The assessment included long COVID symptoms, cardiorespiratory function, neuropsychiatric conditions, quality of life, and laboratory tests. The outcomes included one or more symptoms and/or signs indicative of long COVID, aligning closely with the World Health Organization definition of post-COVID-19 condition.ResultsOf the 346 participants, we included 326 in the analysis. 78% of HS (n/N = 171/219) and 62% of NHS (n/N = 55/89) reported at least one sequela symptom. HS had higher odds of palpitations, headaches, dizziness, sleeping difficulties, brain fog, muscle weakness, joint pain, hypertension, insulin requirement, poor quality of life, and prolonged corrected QT intervals on electrocardiogram compared to NHS at two years (95% confidence interval (CI)>1). Regarding evolution, sequelae-symptoms, neurological outcomes, restrictive spirometry findings, and electrocardiogram abnormalities remained unchanged, although psychiatric sequelae, quality of life, and exercise capacity improved in both groups. Hospital readmission rates significantly increased (P < 0.05). The incidence rates of palpitations, cough, and hypertension were higher in HS compared to NHS (95% CI>1). Two or more vaccine doses decreased the risk of respiratory (adjusted risk ratio (aRR) = 0.76; 95% CI = 0.63-0.91) and psychiatric sequelae (aRR = 0.78; 95% CI = 0.66-0.92) than one or no doses.ConclusionsCOVID-19 survivors, particularly HS, experienced a higher burden of persistent symptoms and health issues two years after infection. However, vaccination significantly reduced the risk of respiratory and psychiatric outcomes. These findings highlight the importance of ongoing vaccination programs and the need for targeted rehabilitation services in low-resource settings.

Dataset Information

Beyond the acute: pain in long COVID survivors at 1.5 years.

Objective

Method

Results

Conclusion

Publications

Beyond the acute: pain in long COVID survivors at 1.5 years.

Similar Datasets

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