Ontology highlight
ABSTRACT:
SUBMITTER: Chen F
PROVIDER: S-EPMC11310205 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Chen Fang F Lu Yukai Y Xu Yang Y Chen Naicheng N Yang Lijing L Zhong Xiaoyi X Zeng Hao H Liu Yanying Y Chen Zijin Z Zhang Qian Q Chen Shilei S Cao Jia J Zhao Jinghong J Wang Song S Hu Mengjia M Wang Junping J
Nature communications 20240808 1
The maintenance of hematopoietic stem cell (HSC) functional integrity is essential for effective hematopoietic regeneration when suffering from injuries. Studies have shown that the innate immune pathways play crucial roles in the stress response of HSCs, whereas how to precisely modulate these pathways is not well characterized. Here, we identify the E3 ubiquitin ligase tripartite motif-containing 47 (Trim47) as a negative regulator of the mitochondrial antiviral-signaling protein (MAVS)-mediat ...[more]