Ontology highlight
ABSTRACT:
SUBMITTER: Nobre L
PROVIDER: S-EPMC4552940 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20150828 8
RIG-I-like receptors detect viral RNA in infected cells and promote oligomerization of the outer mitochondrial membrane protein MAVS to induce innate immunity to viral infection through type I interferon production. Mitochondrial reactive oxygen species (mROS) have been shown to enhance anti-viral MAVS signalling, but the mechanisms have remained obscure. Using a biochemical oligomerization-reporter fused to the transmembrane domain of MAVS, we found that mROS inducers promoted lipid-dependent M ...[more]