Dataset Information

Frequency of Electrocardiogram-Defined Cardiac Conduction Disorders in a Multi-Institutional Primary Care Cohort.

ABSTRACT:

Background

Disorders affecting cardiac conduction are associated with substantial morbidity. Understanding the epidemiology and risk factors for conduction disorders may enable earlier diagnosis and preventive efforts.

Objectives

The purpose of this study was to quantify contemporary frequency and risk factors for electrocardiogram (ECG)-defined cardiac conduction disorders in a large multi-institutional primary care sample.

Methods

We quantified prevalence and incidence of conduction disorders among adults receiving longitudinal primary care between 2001 and 2019, each with at least one 12-lead ECG performed prior to the start of follow-up and at least one ECG during follow-up. We defined conduction disorders using curated terms extracted from ECG diagnostic statements by cardiologists. We grouped conduction disorders by inferred anatomic location of abnormal conduction. We tested associations between clinical factors and incident conduction disease using multivariable proportional hazards regression.

Results

We analyzed 189,163 individuals (median age 55 years; 58% female). The overall prevalence of conduction disorders was 27% among men and 15% among women. Among 119,926 individuals (median age 55 years; 51% female), 6,802 developed an incident conduction system abnormality over a median of 10 years (Q1, Q3: 6, 15 years) of follow-up. Incident conduction disorders were more common in men (8.78 events/1,000 person-years) vs women (4.34 events/1,000 person-years, P < 0.05). In multivariable models, clinical factors including older age (HR: 1.25 per 5-year increase [95% CI: 1.24-1.26]) and myocardial infarction (HR: 1.39 [95% CI: 1.26-1.54]) were associated with incident conduction disorders.

Conclusions

Cardiac conduction disorders are common in a primary care population, especially among older individuals with cardiovascular risk factors.

SUBMITTER: Haimovich JS

PROVIDER: S-EPMC11312782 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature

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Publications

Frequency of Electrocardiogram-Defined Cardiac Conduction Disorders in a Multi-Institutional Primary Care Cohort.

Haimovich Julian S JS Di Achille Paolo P Nauffal Victor V Singh Pulkit P Reeder Christopher C Wang Xin X Sarma Gopal G Kornej Jelena J Benjamin Emelia J EJ Philippakis Anthony A Batra Puneet P Ellinor Patrick T PT Lubitz Steven A SA Khurshid Shaan S

JACC. Advances 20240524 7

<h4>Background</h4>Disorders affecting cardiac conduction are associated with substantial morbidity. Understanding the epidemiology and risk factors for conduction disorders may enable earlier diagnosis and preventive efforts.<h4>Objectives</h4>The purpose of this study was to quantify contemporary frequency and risk factors for electrocardiogram (ECG)-defined cardiac conduction disorders in a large multi-institutional primary care sample.<h4>Methods</h4>We quantified prevalence and incidence of ...[more]

PMID: 39130046

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Dataset Information

Frequency of Electrocardiogram-Defined Cardiac Conduction Disorders in a Multi-Institutional Primary Care Cohort.

Background

Objectives

Methods

Results

Conclusions

Publications

Frequency of Electrocardiogram-Defined Cardiac Conduction Disorders in a Multi-Institutional Primary Care Cohort.

Similar Datasets

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