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A Formal Synthesis of (+)-Hannokinol Using a Chiral Horner-Wittig Reagent.

ABSTRACT: Herein, we report a concise and efficient formal synthesis of (+)-hannokinol. Key to this new strategy is the use of a chiral Horner-Wittig reagent, readily available from 2-deoxy-D-ribose, to introduce the chiral 1,3-diol motif.

SUBMITTER: Tapera M

PROVIDER: S-EPMC11313872 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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A Formal Synthesis of (+)-Hannokinol Using a Chiral Horner-Wittig Reagent.

Tapera Michael M Borghi Federica F Mayer-Figge Jan Lukas JL Mittendorf Fabia F Celik Ibrahim-Ethem IE Gómez-Suárez Adrián A Kirsch Stefan F SF

Molecules (Basel, Switzerland) 20240805 15

Herein, we report a concise and efficient formal synthesis of (+)-hannokinol. Key to this new strategy is the use of a chiral Horner-Wittig reagent, readily available from 2-deoxy-D-ribose, to introduce the chiral 1,3-diol motif. ...[more]

PMID: 39125113

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