Ontology highlight
ABSTRACT:
SUBMITTER: Lister NC
PROVIDER: S-EPMC11317591 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Lister Nicholas C NC Milton Ashley M AM Patel Hardip R HR Waters Shafagh A SA Hanrahan Benjamin J BJ McIntyre Kim L KL Livernois Alexandra M AM Horspool William B WB Wee Lee Kian LK Ringel Alessa R AR Mundlos Stefan S Robson Michael I MI Shearwin-Whyatt Linda L Grützner Frank F Graves Jennifer A Marshall JAM Ruiz-Herrera Aurora A Waters Paul D PD
Proceedings of the National Academy of Sciences of the United States of America 20240729 32
Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between sexes and with autosomes. A need for dosage compensation has long been thought to be critical in vertebrates. However, this was questioned by findings of unequal mRNA abundance measurements in monotreme mammals and birds. Here, we demonstrate unbalanced mRNA levels of X genes in platypus males and females and a correlation with differential loading of histone modifications. We also observed unbalanced tran ...[more]