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Dosage compensation mass spectrometry in platypus, chicken and mouse

ABSTRACT: Gene dosage imbalance of heteromorphic sex chromosomes (XY or ZW) exists between the sexes, and with the autosomes. Mammalian X chromosome inactivation was long thought to imply a critical need for dosage compensation in vertebrates. However, mRNA abundance measurements that demonstrated sex chromosome transcripts are neither balanced between the sexes or with autosomes in monotreme mammals or birds brought sex chromosome dosage compensation into question. This study examines transcriptomic and proteomic levels of dosage compensation in platypus and chicken compared to mouse, a model eutherian species. We analyzed mRNA and protein levels in heart and liver tissues of chicken, mouse and platypus.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Gallus Gallus (chicken) Ornithorhynchus Anatinus Mus Musculus (mouse)

TISSUE(S): Heart, Liver

SUBMITTER: Nicholas Lister

LAB HEAD: Paul D. Waters

PROVIDER: PXD040182 | Pride | 2024-07-30

REPOSITORIES: Pride

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			Action	DRS
	KWL-15-5-18-iTRAQ-C-Liv-4h-HR-1.wiff	Wiff
	KWL-15-5-18-iTRAQ-C-Liv-4h-HR-1.wiff.scan	Wiff
	KWL-15-5-18-iTRAQ-C-Liv-4h-HR-2.wiff	Wiff
	KWL-15-5-18-iTRAQ-C-Liv-4h-HR-2.wiff.scan	Wiff
	KWL-15-5-18-iTRAQ-C-Liv-4h-HR-Gallus.group	Other

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