Ontology highlight
ABSTRACT:
SUBMITTER: Santini BL
PROVIDER: S-EPMC11318538 | biostudies-literature | 2024 Dec
REPOSITORIES: biostudies-literature
Santini Brianda L BL Gaardløs Margrethe M Wyrzykowski Dariusz D Rothemund Sven S Penk Anja A Zacharias Martin M Samsonov Sergey A SA
Computational and structural biotechnology journal 20240720
Cyclic peptides present a robust platform for drug design, offering high specificity and stability due to their conformationally constrained structures. In this study, we introduce an updated version of the Cyclic Peptide Matching program (cPEPmatch) tailored for the identification of cyclic peptides capable of mimicking protein-glycosaminoglycan (GAG) binding sites. We focused on engineering cyclic peptides to replicate the GAG-binding affinity of antithrombin III (ATIII), a protein that plays ...[more]