Ontology highlight
ABSTRACT:
SUBMITTER: Gesteira TF
PROVIDER: S-EPMC5299588 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Gesteira Tarsis Ferreira TF Coulson-Thomas Vivien J VJ Yuan Yong Y Zhang Jianhua J Nader Helena B HB Kao Winston W-Y WW
Scientific reports 20170209
Lumican, a small leucine rich proteoglycan (SLRP), is a component of extracellular matrix which also functions as a matrikine regulating multiple cell activities. In the cornea, lumican maintains corneal transparency by regulating collagen fibrillogenesis, promoting corneal epithelial wound healing, regulating gene expression and maintaining corneal homeostasis. We have recently shown that a peptide designed from the 13 C-terminal amino acids of lumican (LumC13) binds to ALK5/TGFBR1 (type1 recep ...[more]