Ontology highlight
ABSTRACT:
SUBMITTER: Talvard-Balland N
PROVIDER: S-EPMC11324309 | biostudies-literature | 2024 Jun
REPOSITORIES: biostudies-literature
Talvard-Balland Nana N Braun Lukas M LM Dixon Karen O KO Zwick Melissa M Engel Helena H Hartmann Alina A Duquesne Sandra S Penter Livius L Andrieux Geoffroy G Rindlisbacher Lukas L Acerbis Andrea A Ehmann Jule J Köllerer Christoph C Ansuinelli Michela M Rettig Andres A Moschallski Kevin K Apostolova Petya P Brummer Tilman T Illert Anna L AL Schramm Markus A MA Cheng Yurong Y Köttgen Anna A Duyster Justus J Menssen Hans D HD Ritz Jerome J Blazar Bruce R BR Boerries Melanie M Schmitt-Gräff Annette A Sariipek Nurefsan N Van Galen Peter P Buescher Joerg M JM Cabezas-Wallscheid Nina N Pahl Heike L HL Pearce Erika L EL Soiffer Robert J RJ Wu Catherine J CJ Vago Luca L Becher Burkhard B Köhler Natalie N Wertheimer Tobias T Kuchroo Vijay K VK Zeiser Robert R
The Journal of clinical investigation 20240625 16
Leukemia relapse is a major cause of death after allogeneic hematopoietic cell transplantation (allo-HCT). We tested the potential of targeting T cell (Tc) immunoglobulin and mucin-containing molecule 3 (TIM-3) for improving graft-versus-leukemia (GVL) effects. We observed differential expression of TIM-3 ligands when hematopoietic stem cells overexpressed certain oncogenic-driver mutations. Anti-TIM-3 Ab treatment improved survival of mice bearing leukemia with oncogene-induced TIM-3 ligand exp ...[more]