Clinical significance of sarcopenia in children with neuroblastic tumors.
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ABSTRACT: Purpose
To elucidate the clinical significance of sarcopenia in children with neuroblastic tumors (NTs).Methods
We conducted a retrospective observational study and analyzed the z-scores for height, body weight, body mass index, and skeletal muscle index (HT-z, BW-z, BMI-z, and SMI-z) along with the clinical characteristics of 36 children with NTs. SMI-z was calculated from 138 computed tomography scans at diagnosis, during treatment, and at follow-up. The International Neuroblastoma Risk Group classification was used to identify high-risk groups. We analyzed the data at diagnosis for prognostic analysis and changes over time after diagnosis in the HT-z, BW-z, BMI-z, and SMI-z groups.Results
Among the four parameters at diagnosis, only SMI-z predicted overall survival (hazard ratio, 0.58; 95% confidence interval, 0.34-0.99). SMI-z, HT-z, and BW-z significantly decreased over time after diagnosis (P < 0.05), while BMI-z did not (P = 0.11). In surviving high-risk NT cases without disease, SMI-z, HT-z, and BW-z significantly decreased over time (P < 0.05), while BMI-z did not (P = 0.43).Conclusion
In children with NT, the SMI-z at diagnosis was a significant prognostic factor and decreased during treatment and follow-up along with HT-z and BW-z. Monitoring muscle mass is important because sarcopenia may be associated with growth impairment.
SUBMITTER: Kudo W
PROVIDER: S-EPMC11335913 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Publications
Clinical significance of sarcopenia in children with neuroblastic tumors.
Kudo Wataru W Terui Keita K Furugane Ryoya R Takenouchi Ayako A Komatsu Shugo S Kawaguchi Yunosuke Y Nishimura Katsuhiro K Katsumi Daisuke D Hishiki Tomoro T
Pediatric surgery international 20240821 1
<h4>Purpose</h4>To elucidate the clinical significance of sarcopenia in children with neuroblastic tumors (NTs).<h4>Methods</h4>We conducted a retrospective observational study and analyzed the z-scores for height, body weight, body mass index, and skeletal muscle index (HT-z, BW-z, BMI-z, and SMI-z) along with the clinical characteristics of 36 children with NTs. SMI-z was calculated from 138 computed tomography scans at diagnosis, during treatment, and at follow-up. The International Neuroblas ...[more]
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