Vascular patterns provide therapeutic targets in aggressive neuroblastic tumors.
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ABSTRACT:
SUBMITTER: Tadeo I
PROVIDER: S-EPMC4991429 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Vascular patterns provide therapeutic targets in aggressive neuroblastic tumors.
Tadeo Irene I Bueno Gloria G Berbegall Ana P AP Fernández-Carrobles M Milagro MM Castel Victoria V García-Rojo Marcial M Navarro Samuel S Noguera Rosa R
Oncotarget 20160401 15
Angiogenesis is essential for tumor growth and metastasis, nevertheless, in NB, results between different studies on angiogenesis have yielded contradictory results. An image analysis tool was developed to characterize the density, size and shape of total blood vessels and vascular segments in 458 primary neuroblastic tumors contained in tissue microarrays. The results were correlated with clinical and biological features of known prognostic value and with risk of progression to establish histol ...[more]
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