Reduction of anti-leishmanial pentavalent antimonial drugs by a parasite-specific thiol-dependent reductase, TDR1.
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ABSTRACT:
SUBMITTER: Denton H
PROVIDER: S-EPMC1133846 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Publications
Reduction of anti-leishmanial pentavalent antimonial drugs by a parasite-specific thiol-dependent reductase, TDR1.
Denton Helen H McGregor Joanne C JC Coombs Graham H GH
The Biochemical journal 20040701 Pt 2
The reason why Leishmania parasites are susceptible to organic antimonial drugs, the standard chemotherapeutic agents for over 50 years, apparently lies in the fact that the mammalian stage of the parasite reduces the pentavalent form of the administered drug to a trivalent form that causes parasite death. We have identified and characterized a parasite-specific enzyme that can catalyse the reduction of pentavalent antimonials and may therefore be central to the anti-parasite activity of the dru ...[more]
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