RIT-seq analysis of the anti-leishmanial drugs
Ontology highlight
ABSTRACT:
PROVIDER: PRJEB31973 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| ERR3261666_1.fastq.gz | Fastqsanger.gz | |||
| ERR3261666_2.fastq.gz | Fastqsanger.gz | |||
| ERR3261667_1.fastq.gz | Fastqsanger.gz | |||
| ERR3261667_2.fastq.gz | Fastqsanger.gz | |||
| ERR3261668_1.fastq.gz | Fastqsanger.gz |
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Project description:Glycolysis is the sole free-energy source for the deadly parasite Trypanosoma brucei and is therefore a possible target pathway for anti-trypanosomal drugs. Plasma-membrane glucose transport exerts high control over trypanosome glycolysis and hence the transporter is a promising drug target. Here we show that at high inhibitor concentrations, inhibition of trypanosome glucose transport causes cell death. Most interestingly, sublethal concentrations initiate a domino effect in which network adaptations enhance inhibition. total of 5 slides, including 3 biological replicates and dyeswap
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