Ontology highlight
ABSTRACT:
SUBMITTER: Dinarina A
PROVIDER: S-EPMC1134800 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Dinarina Ana A Perez Laurent H LH Davila Amparo A Schwab Markus M Hunt Tim T Nebreda Angel R AR
The Biochemical journal 20050301 Pt 2
Progression through the cell cycle is regulated by CDKs (cyclin-dependent kinases), which associate with activating partners, named cyclins, to efficiently phosphorylate substrates. We previously reported the identification of RINGO, a Xenopus protein that can activate CDK1 and CDK2 despite lack of sequence similarity to cyclins, which plays a role in the regulation of the meiotic cell cycle in oocytes. In the present study we report the characterization of four mammalian RINGO proteins, which a ...[more]