Ontology highlight
ABSTRACT:
SUBMITTER: Shu F
PROVIDER: S-EPMC1890480 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20070521 22
Cyclin-dependent kinases (CDKs) are crucial regulators of the eukaryotic cell cycle whose activities are controlled by associated cyclins. PFTK1 shares limited homology to CDKs, but its ability to associate with any cyclins and its biological functions remain largely unknown. Here, we report the functional characterization of human PFTK1 as a CDK. PFTK1 specifically interacted with cyclin D3 (CCND3) and formed a ternary complex with the cell cycle inhibitor p21(Cip1) in mammalian cells. We demon ...[more]