Ontology highlight
ABSTRACT:
SUBMITTER: Rissone P
PROVIDER: S-EPMC11348302 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Rissone Paolo P Severino Aurélien A Pastor Isabel I Ritort Felix F
Proceedings of the National Academy of Sciences of the United States of America 20240816 34
RNA's diversity of structures and functions impacts all life forms since primordia. We use calorimetric force spectroscopy to investigate RNA folding landscapes in previously unexplored low-temperature conditions. We find that Watson-Crick RNA hairpins, the most basic secondary structure elements, undergo a glass-like transition below [Formula: see text]C where the heat capacity abruptly changes and the RNA folds into a diversity of misfolded structures. We hypothesize that an altered RNA bioche ...[more]