Dataset Information

Emergence of bla _NDM-1-carrying Enterobacter chengduensis in China.

ABSTRACT:

Introduction

Enterobacter chengduensis was defined as a novel species in the genus. Enterobacter in 2019, however, antimicrobial resistance, such as carbapenem resistance, has rarely been described in E. chengduensis. This study described the molecular features of four carbapenem-resistant E. chengduensis strains collected from a tertiary health care hospital in Southwest China.

Methods

Whole genome sequencing (WGS) was used to determine the genome sequence of four E. chengduensis strains. The precise species of strains were identified by average nucleotide identity (ANI) and in silico DNA-DNA hybridization (isDDH). The clonal relatedness of four E. chengduensis strains and additional 15 ones from NCBI were examined through phylogenetic analysis. The molecular features of E. chengduensis and genetic structure of carbapenemase- encoding plasmids were characterized through genomic annotation and analysis.

Results

The results revealed the emergence of bla _NDM-1-carrying E. chengduensis strains in China. Multilocus sequence typing (MLST) analysis showed that all 19 E. chengduensis belonged to the same sequence type of ST414. Core SNP analysis suggested the potential intrahospital clonal transmission of ST414 E. chengduensis. The carbapenemase-encoding gene bla _NDM-1 was harbored by an IncC-type plasmid, which was experimentally confirmed to be able to conjugate.

Discussion

This study reports the first emergence and potential clonal transmission of bla _NDM-1-carrying E. chengduensis. Further surveillance should be advocated to monitor the dissemination of carbapenem-resistant E. chengduensis and bla _NDM-1-harboring IncC-type plasmids in China.

SUBMITTER: Fu H

PROVIDER: S-EPMC11350614 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Publications

Emergence of <i>bla</i> <sub>NDM-1</sub>-carrying <i>Enterobacter chengduensis</i> in China.

Fu Hongyu H Zhu Zhichen Z Wang Xiao X Lv Jingnan J Zhu Jie J Chen Liang L Yu Hua H Du Hong H

Frontiers in microbiology 20240814

<h4>Introduction</h4><i>Enterobacter chengduensis</i> was defined as a novel species in the genus. <i>Enterobacter</i> in 2019, however, antimicrobial resistance, such as carbapenem resistance, has rarely been described in <i>E. chengduensis</i>. This study described the molecular features of four carbapenem-resistant <i>E. chengduensis</i> strains collected from a tertiary health care hospital in Southwest China.<h4>Methods</h4>Whole genome sequencing (WGS) was used to determine the genome sequ ...[more]

PMID: 39206374

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Dataset Information

Emergence of bla _NDM-1-carrying Enterobacter chengduensis in China.

Introduction

Methods

Results

Discussion

Publications

Emergence of <i>bla</i> <sub>NDM-1</sub>-carrying <i>Enterobacter chengduensis</i> in China.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Emergence of bla NDM-1-carrying Enterobacter chengduensis in China.

Introduction

Methods

Results

Discussion

Publications

Emergence of <i>bla</i> <sub>NDM-1</sub>-carrying <i>Enterobacter chengduensis</i> in China.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Emergence of bla _NDM-1-carrying Enterobacter chengduensis in China.