Ontology highlight
ABSTRACT:
SUBMITTER: Signal B
PROVIDER: S-EPMC11353134 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Signal Brandon B Phipps Andrew J AJ Giles Katherine A KA Huskins Shannon N SN Mercer Timothy R TR Robinson Mark D MD Woodhouse Adele A Taberlay Phillippa C PC
Cells 20240821 16
Neurons are central to lifelong learning and memory, but ageing disrupts their morphology and function, leading to cognitive decline. Although epigenetic mechanisms are known to play crucial roles in learning and memory, neuron-specific genome-wide epigenetic maps into old age remain scarce, often being limited to whole-brain homogenates and confounded by glial cells. Here, we mapped H3K4me3, H3K27ac, and H3K27me3 in mouse neurons across their lifespan. This revealed stable H3K4me3 and global lo ...[more]