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Design and Fabrication of Tryptophan Sensor Using Voltammetric Method.

ABSTRACT: L-tryptophan is an amino acid that significantly impacts metabolic activity in both humans and herbivorous animals. It is also known as a precursor for melatonin and serotonin, and its levels must be regulated in the human body. Therefore, there is a need to develop a cost-effective, simple, sensitive, and selective method for detecting L-tryptophan. Herein, we report the fabrication of an L-tryptophan sensor using a nickel-doped tungsten oxide ceramic-modified electrode. The Ni-WO₃ was synthesized using simple strategies and characterized by various advanced techniques such as powder X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and photoelectron X-ray spectroscopy. Furthermore, a glassy carbon electrode was modified with the synthesized Ni-WO₃ and explored as the L-tryptophan (L-TRP) sensor. Cyclic voltammetry and differential pulse voltammetry were used to investigate the sensing ability of the modified electrode (Ni-WO₃/GC). The Ni-WO₃/GC exhibited an excellent limit of detection of 0.4 µM with a good dynamic linear range. The Ni-WO₃/GC also demonstrated excellent selectivity in the presence of various electroactive molecules. The Ni-WO₃/GC also showed decent reproducibility, repeatability, stability, and storage stability. This work proposes the fabrication of novel Ni-WO₃/GC for the sensing of L-tryptophan. So far, no report is available on the use of Ni-WO₃/GC for the sensing of L-TRP. This is the first report on the use of Ni-WO₃/GC for the sensing of L-TRP sensing applications.

SUBMITTER: Khan MQ

PROVIDER: S-EPMC11356631 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Design and Fabrication of Tryptophan Sensor Using Voltammetric Method.

Khan Mohd Quasim MQ Ahmad Khursheed K Khan Rais Ahmad RA

Micromachines 20240818 8

L-tryptophan is an amino acid that significantly impacts metabolic activity in both humans and herbivorous animals. It is also known as a precursor for melatonin and serotonin, and its levels must be regulated in the human body. Therefore, there is a need to develop a cost-effective, simple, sensitive, and selective method for detecting L-tryptophan. Herein, we report the fabrication of an L-tryptophan sensor using a nickel-doped tungsten oxide ceramic-modified electrode. The Ni-WO<sub>3</sub> w ...[more]

PMID: 39203698

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Project description:In this research article, an organic polymer based polypyrrole (Ppy) composite material has been synthesized and analyzed for the design and fabrication purposes of a fast-responsive, highly sensitive, and an economical resistive-type novel humidity detection sensor. This humidity sensor most suitably serves the purpose for industrial humidity (i.e., values ranging from low to high) detection applications. First, a polypyrrole composite material (a mixture of polypyrrole, polypyrrole-NiO, polypyrrole-CeO2, and polypyrrole-Nb2O5) has been synthesized by chemical oxidative polymerization method, and then is treated at various temperatures, i.e., 100, 150 and 200 °C, respectively. After this treatment, the synthesized samples were then characterized by using FTIR, SEM, and DTA/TGA techniques for analyzing humidity sensing properties. The polypyrrole samples with the best morphological structure and properties were then incorporated on interdigitated electrodes. For the fabrication purposes of this thin film structure, at first a few drops of polyvinyl alcohol (PVA) were placed over interdigitated electrodes (IDE) and then the synthesized polypyrrole composite was uniformly deposited in the form of a thin film over it. The plots show that this is a good resistive-type humidity detection device for the relative humidity range of 30% to 90%. The response and recovery times of this newly fabricated humidity sensor were reported to be the same as 128 s at room temperature. Additionally, the stability and the repeatability response behavior of this Ppy sensor were verified up to five cycles of multiple repetitions. This presents an excellent stability and repeatability performance of the sensor. Furthermore, the capacitances versus humidity response and recovery properties of the designed sensor were studied too. This illustrates an excellent capacitive verses humidity response and shows a linear and an active behavior. Lastly, the experimental result proves that polypyrrole composite thin film shows a reasonable best performance up to a temperature of 100 °C.

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Design and Fabrication of Tryptophan Sensor Using Voltammetric Method.

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Design and Fabrication of Tryptophan Sensor Using Voltammetric Method.

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