Ontology highlight
ABSTRACT:
SUBMITTER: Sitbon YH
PROVIDER: S-EPMC11357882 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Sitbon Yoel H YH Kazmierczak Katarzyna K Liang Jingsheng J Kloehn Andrew J AJ Vinod Judith J Kanashiro-Takeuchi Rosemeire R Szczesna-Cordary Danuta D
iScience 20240726 8
We investigated the role of the N-terminus (residues 1-43) of the myosin essential light chain (N-ELC) in regulating cardiac function in hypertrophic (HCM-A57G) and restrictive (RCM-E143K) cardiomyopathy mice. Both models were cross-genotyped with N-ELC-truncated Δ43 mice, and the offspring were studied using echocardiography and muscle contractile mechanics. In A57G×Δ43 mice, Δ43 expression improved heart function and reduced hypertrophy and fibrosis. No improvements were seen in E143K×Δ43 comp ...[more]